Dane starred as family patriarch Cal Jacobs on hit HBO teen drama Euphoria. Before that, he was perhaps best known as Dr Mark Sloan, or "Dr McSteamy", on medical drama Grey's Anatomy.
The California-born actor shared his ALS diagnosis in April 2025 and spent his final months raising funds and awareness for the most common form of motor neurone disease (MND).
His family said in a statement: "With heavy hearts, we share that Eric Dane passed on Thursday afternoon following a courageous battle with ALS."